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Test Code CELAB ELM Celiac Disease Antibodies, Serum

Specimen Collection Requirements

SPECIMEN COLLECTION REQUIREMENTS:            
Name Celiac Disease Antibodies         
Alt name Celiac Disease Panel, TTG IgA and TTG IgG Antibodies    
Dept Chemistry            
Collection Cont. SST              
Specimen Serum aliquot            
Transport temp Frozen          
Specimen Volume Preferred Volume: 1 mL; Minimum Volume: 0.5 mL       
Also acceptable Red Top Tube            
TECHNICAL SPECIFICATIONS:              
Performed Tuesdays and Thursdays          
Reported Tuesdays and Thursdays            
Methodology Fluoroenzymeimmunoassay (FEIA)          
CPT TTG IgA: 86364; TTG IgG: 86364          
LOINC TTG IgA: 46128-5; TTG IgG: 56537-4          
Stability Frozen for transport; Refrigerated: 14 Days
Ref range:  Negative: <7 U/mL; Equivocal: 7-10 U/mL; Positive: >10 U/mL    
Notes Celiac disease is a life-long condition in which ingestion of gluten, the water insoluble wheat-gliadin and the prolamins in rye and barley, leads to chronic inflammation and damage of the small intestinal mucosa. Tissue transglutaminase has been identified as the major autoantigen in celiac disease. IgA antibodies against tTG are highly disease specific serological markers for celiac disease and dermatitis herpetiformis. tTG IgG antibodies are less specific for these diseases but are helpful markers in patients with IgA deficiency.