SPECIMEN COLLECTION REQUIREMENTS: |
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Name |
Celiac Disease Antibodies |
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Alt name |
Celiac Disease Panel, TTG IgA and TTG IgG Antibodies |
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Dept |
Chemistry |
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Collection Cont. |
SST |
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Specimen |
Serum aliquot |
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Transport temp |
Frozen |
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Specimen Volume |
Preferred Volume: 1 mL; Minimum Volume: 0.5 mL |
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Also acceptable |
Red Top Tube |
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TECHNICAL SPECIFICATIONS: |
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Performed |
Tuesdays and Thursdays |
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Reported |
Tuesdays and Thursdays |
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Methodology |
Fluoroenzymeimmunoassay (FEIA) |
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CPT |
TTG IgA: 86364; TTG IgG: 86364 |
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LOINC |
TTG IgA: 46128-5; TTG IgG: 56537-4 |
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Stability |
Frozen for transport; Refrigerated: 14 Days |
Ref range: |
Negative: <7 U/mL; Equivocal: 7-10 U/mL; Positive: >10 U/mL |
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Notes |
Celiac disease is a life-long condition in which ingestion of gluten, the water insoluble wheat-gliadin and the prolamins in rye and barley, leads to chronic inflammation and damage of the small intestinal mucosa. Tissue transglutaminase has been identified as the major autoantigen in celiac disease. IgA antibodies against tTG are highly disease specific serological markers for celiac disease and dermatitis herpetiformis. tTG IgG antibodies are less specific for these diseases but are helpful markers in patients with IgA deficiency. |
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